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Collision induced dissociation of peptide bonds in msms spectra
Products & Services
Sample Submission
Instrumentation
System Suitability
Capabilities
Fragment mass assignments for spectra
Discover protein-protein interfaces in solution | Discover drug-binding sites on proteins in solution | Determine protein three-dimensional structure | Analyze saliva/sweat/blood/urine to discover current protein profile | Identify the protein associated with your activity | Identify the natural product associated with your activity
Discover protein-protein interfaces in solution
Discover drug-binding sites on proteins in solution
Determine protein three-dimensional structure
Guidelines to submit plasmids encoding proteins for expression and analysis:
Analyze saliva/sweat/blood/urine to discover current protein profile
Guidelines to submit fluid samples:
Identify the protein associated with your activity
Guidelines to submit proteins
Guidelines to submit proteins in gel-slices
Identify the natural product associated with your activity
Guidelines to submit natural product fractions
Sample Submission
To submit plasmids encoding proteins for expression and analysis: guidelines.
To submit fluid samples: guidelines.
To submit proteins: guidelines.
To submit proteins in gel-slices: guidelines.
To submit natural product fractions: guidelines.
Instrumentation
Nano LCMSMS capability
Using a Waters nanoAcquity ultra pressure liquid chromatography system, in-line nanospray ionization, and a Thermo Deca XP+ ion trap mass spectrometer, our nano LCMSMS setup can give the customer robust peptide identification from samples containing 100 fmols of material.
Protein identification from proteolytic digests
Using the latest version of the Discoverer 1.0 (replaced Sequest) peptide and protein assignment software and our years of experience assigning peptide spectra, Martin-Protean can provide careful and thorough protein assigment from the peptide spectra generated from your samples.
System Suitability
The data you need when you need it: our current ESI-LCMSn system suitability run.
Capabilities
Martin-Protean has extensive experience in:
- labeling intact proteins and isolating the labeled peptide from the proteolysis
- synthesizing and implementing protein modification reagents
- modifying intact proteins without perturbing protein structure
- modifying intact proteins in denaturant to near completion
- producing protein with genetically encoded reactive probes
- 96-well protein-precipitation, proteolysis and LCMSn analysis
- Peptide and modified peptide LCMSn spectral analysis
- handling saliva, sweat, blood and urine samples
- protein expression and purification
- mutagenesis, subcloning, SDS-PAGE, Western Blots.